Hypoxic cell radiosensitization by moderate hyperthermia and glucose deprivation

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575997· OSTI ID:5742213

Kim, J H; Kim, S H; Hahn, E W

Cell culture studies were carried out to determine whether moderate hyperthermia reduces the oxygen enhancement ratio of cells under well-defined cultural conditions. Using asynchronously growing HeLa cells, the OER of cells with and without glucose was determined following exposure of cells to moderate hyperthermia, 40.5omicronC for 1 hr, immediately after X irradiation. The OER of cells with 5 mM glucose was 3.2, whereas the OER of glucose-deprived cells was reduced to 2.0. The pH of the cell culture medium was kept at 7.4 throughtout the experiments. The present finding may provide a clue toward further enhancing the radiosensitization of hypoxic cells by heat.

• Research Organization: Memorial Sloan-Kettering Cancer Center, NY
• OSTI ID: 5742213
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
BODY TEMPERATURE
CARBOHYDRATES
CELL KILLING
DATA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GLUCOSE
HELA CELLS
HEXOSES
HYPERTHERMIA
INFORMATION
IONIZING RADIATIONS
MONOSACCHARIDES
NUMERICAL DATA
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXYGEN ENHANCEMENT RATIO
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SACCHARIDES
SURVIVAL CURVES
X RADIATION