Toluene embryopathy

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Pediatr.; (United States)

DOI:https://doi.org/10.1016/S0022-3476(85)80238-9· OSTI ID:6376991

Hersh, J H; Podruch, P E; Rogers, G; Weisskopf, B

Three children with microcephaly, central nervous system dysfunction, minor craniofacial and limb anomalies, and variable growth deficiency were born to women who inhaled large quantities of pure toluene throughout pregnancy. The features in there patients were reminiscent of the patterns of malformation previously described following in utero exposure to alcohol, certain anticonvulsants, and hyperphenylalaninemia. It is possible that there is a variable and nonspecific teratogenic phenotype characterized by alterations in growth, development, and morphogenesis. Careful evaluation and monitoring of infants exposed to toluene in utero are needed to determine the significance of these findings.

• OSTI ID: 6376991
• Journal Information: J. Pediatr.; (United States), Journal Name: J. Pediatr.; (United States) Vol. 6; ISSN JOPDA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATED AROMATICS
AROMATICS
BIOLOGICAL EFFECTS
CONGENITAL MALFORMATIONS
DISEASES
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INHALATION
INTAKE
MALFORMATIONS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PREGNANCY
PROGENY
TERATOGENESIS
TOLUENE