Inhibition of rat nasal cytochrome P-450-dependent mono-oxygenase by the essence heliotropin (piperonal)
Journal Article
·
· Drug Metab. Dispos.; (United States)
OSTI ID:6373908
The purpose of this study was to determine if heliotropin can inhibit cytochrome P-450 mediated oxidations in both nasal and hepatic microsomes. Heliotropin was an effective inhibitor of the methylation of the common fragrance dimethyl anthranilate by nasal microsomes; little inhibition was observed in liver microsomes. If the strong inhibitory activity of heliotropin in the nose occurs in vivo, then the inhalation of heliotropin prior to or along with inhalation of other airborne substances might profoundly alter the biological fate of those substances. (RJC)
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 6373908
- Journal Information:
- Drug Metab. Dispos.; (United States), Journal Name: Drug Metab. Dispos.; (United States) Vol. 10:5; ISSN DMDSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
ANTHRANILIC ACID
BIOCHEMICAL REACTION KINETICS
BODY
BODY AREAS
CARBOXYLIC ACIDS
DATA
DIGESTIVE SYSTEM
ENZYME INHIBITORS
ENZYMES
EPITHELIUM
ESTERS
EXPERIMENTAL DATA
FACE
GLANDS
HEAD
IN VITRO
INFORMATION
KINETICS
LIVER
MAMMALS
METABOLISM
MIXED-FUNCTION OXIDASES
NOSE
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
ANTHRANILIC ACID
BIOCHEMICAL REACTION KINETICS
BODY
BODY AREAS
CARBOXYLIC ACIDS
DATA
DIGESTIVE SYSTEM
ENZYME INHIBITORS
ENZYMES
EPITHELIUM
ESTERS
EXPERIMENTAL DATA
FACE
GLANDS
HEAD
IN VITRO
INFORMATION
KINETICS
LIVER
MAMMALS
METABOLISM
MIXED-FUNCTION OXIDASES
NOSE
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES