Cytochrome P-450-dependent monooxygenases in olfactory epithelium of dogs: possible role in tumorigenicity

Journal Article · Thu Apr 01 23:00:00 EST 1982 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7063870· OSTI ID:5543482

Dahl, A R ^[1]; Hadley, W M; Hahn, F F; Benson, J M; McClellan, R O

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1. Inhalation Toxicology Research Inst., Albuquerque, NM

The respiratory tract epithelium of dogs, from the nose to the lungs, was examined for cytochrome P-450 and associated biotransformation activities. In the ethmoturbinates, where olfactory epithelium is located, the amount of cytochrome P-450 was comparable to that in the liver, when measured on the basis of activity per milligram of microsomal protein. The rest of the nasal region also contained large quantities of cytochrome P-450. The presence of these enzymes in the nose may be important in chemical-induced tumorigenesis. The nasal carcinogen hexamethylphosphoramide was shown to be metabolized by nasal microsomal enzymes to another nasal carcinogen, formaldehyde.

• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5543482
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 216; ISSN SCIEA
• Country of Publication: United States
• Language: English

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550200 -- Biochemistry
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BEAGLES
BODY
BODY AREAS
CARCINOGENESIS
CARCINOGENS
CELL CONSTITUENTS
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DOGS
ENZYME ACTIVITY
ENZYMES
FACE
GLANDS
HEAD
INHALATION
INTAKE
LIVER
LUNGS
MAMMALS
METABOLISM
METABOLITES
MICROSOMES
NOSE
ORGANOIDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PATHOGENESIS
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
VERTEBRATES