Retention of ingested latex particles in Peyer's patches of germ-free and conventional mice
Journal Article
·
· Proc. Soc. Exp. Biol. Med.; (United States)
Conventional and germ-free mice ingested a suspension of 2-..mu..m latex particles in drinking water for a 15-day period. Number and distribution of intestinal Peyer's patches did not differ significantly in the two types of mice. Cleared Peyer's patches were compared with regard to size and particle content. The location of particles within Peyer's patch follicles of germ-free mice was similar to that of conventional mice, but the latter had significantly larger follicles and greater accumulations of latex particles. Latex concentration varied with patch location. Proximal patches contained the majority of particles in germ-free mice, whereas particles were most abundant in distal patches of conventional mice. The results show that particle uptake into Peyer's patches takes place even in the complete absence of bacteria in the gut.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6371739
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 179:4; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BIOLOGICAL ACCUMULATION
BODY
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
DRINKING WATER
ELASTOMERS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
HYDROGEN COMPOUNDS
INFORMATION
INGESTION
INTAKE
INTESTINES
LATEX
LYMPHATIC SYSTEM
MAMMALS
MICE
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
POLYMERS
RETENTION
RODENTS
RUBBERS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
WATER
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BIOLOGICAL ACCUMULATION
BODY
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
DRINKING WATER
ELASTOMERS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
HYDROGEN COMPOUNDS
INFORMATION
INGESTION
INTAKE
INTESTINES
LATEX
LYMPHATIC SYSTEM
MAMMALS
MICE
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
POLYMERS
RETENTION
RODENTS
RUBBERS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
WATER