Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures: Progress report for period September 1, 1986-August 31, 1987

Technical Report · Mon Jun 01 04:00:00 EDT 1987

OSTI ID:6366121

Heineman, W R

The long-range objective of this research is the development of more efficacious technetium-99m radiopharmaceuticals for use as imaging agents in diagnostic nuclear medicine. The author developed analytical techniques that are capable of separating radiopharmaceutical mixtures into their component technetium complexes for subsequent evaluation. During this one-year period, a chromatographic procedure has been developed for the separation of technetium phosphonoacetic acid (PAA) complexes and five Tc-PAA complexes have been isolated from radiopharmaceutical preparations. The concentration of each complex in the preparation varies significantly depending on the pH of the preparation. Radiopharmaceutical preparations based on the ligand methylene diphosphonate (MDP) have been prepared by electrochemical reduction of TcO/sub 4//sup -/. The yields of different Tc-MDP complexes are affected by the potential applied to the electrochemical cell. The control of both potential and pH enables a specific Tc-MDP complex to be produced in purer form and higher yield than by chemical reduction. An EXAFS spectrum of a solution of chromatographically isolated Tc-HEDP (hydroxyethylidine diphosphonate) complex shows evidence for a Tc-Tc bond, which is supportive of the postulated oligomeric/polymeric nature of these complexes. 9 refs., 4 figs.

• Research Organization: Cincinnati Univ., OH (USA). Dept. of Chemistry
• DOE Contract Number: FG02-86ER60487
• OSTI ID: 6366121
• Report Number(s): DOE/ER/60487-1; ON: DE87010822
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400202* -- Isotope Effects
Isotope Exchange
& Isotope Separation
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
CHROMATOGRAPHY
COMPLEXES
DRUGS
FRACTIONATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTROSCOPY
NUCLEI
ODD-EVEN NUCLEI
PH VALUE
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SPECTROSCOPY
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
X-RAY SPECTROSCOPY
YEARS LIVING RADIOISOTOPES