Molecular and cellular markers of toxicity in the Japanese Medaka @

Conference · Mon Jan 01 04:00:00 EST 1990

OSTI ID:6360811

Shugart, L R; McCarthy, J F; D'Surney, S J; Greeley, Jr, M S; Hull, C G

The Japanese Medaka (Oryzias latipes) has been recommended for use as a model organism to detect carcinogenic, teratogenic, cytotoxic, and genotoxic compounds in aquatic systems. Because a long latent period often occurs between initial contact with deleterious chemicals and subsequent expression of the pathology, we are investigating early biologically-relevant responses that can be used as genotoxicity markers of exposure and effect. This project focuses on the development of genotoxic bioassays and experimental protocols for exposing Japanese Medaka to genotoxic compounds. 21 refs., 8 figs, 2 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: DOD; DOE/ER
• OSTI ID: 6360811
• Report Number(s): CONF-9008165-1; ON: DE91001923; CNN: Project 1016-B047-A1
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
551000 -- Physiological Systems
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BENZOPYRENE
BIOASSAY
BIOLOGICAL INDICATORS
BIOLOGICAL MARKERS
CONDENSED AROMATICS
DNA
ENVIRONMENTAL EXPOSURE
FISHES
HYDROCARBONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
REPRODUCTION
STRAND BREAKS
TOXICITY
VERTEBRATES