Toxicity of chlorinated diphenyl ethers to embryos of Japanese medaka
- Trent Univ., Peterborough, Ontario (Canada). Environmental and Resource Studies
Polychlorinated diphenyl ethers (PCDEs) are halogenated aromatic hydrocarbons (HAHs) which have been detected in aquatic biota from Europe and North America. In order to determine whether these compounds are a toxic hazard to fish, selected PCDEs were synthesized and tested for embryotoxic potency with embryos of the Japanese medaka (Oryzias latipes). A non-ortho substituted (3,3{prime},4,4{prime},5) PCDE compounds was the most embryotoxic PCDE tested and the toxic equivalency factor (TEF) calculated for this compound were moderately embryotoxic. Pathologic lesions observed in embryos exposed to 2,3,7,8-TCDD and non-ortho PCBs. These data indicate that PCDEs are an additional class of toxic HAHs but the structure-activity relationships that govern toxicity may be different from other compounds in this group.
- OSTI ID:
- 42914
- Report Number(s):
- CONF-9410273--
- Country of Publication:
- United States
- Language:
- English
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