Assessment of the toxic potential of PCB congener 81 (3,4,4[prime],5-tetrachlorobiphenyl) to fish in relation to other non-ortho-substituted PCB congeners
- Trent Univ., Peterborough, Ontario (Canada). Environmental and Resource Studies Program
PCB congener 81 (3,4,4[prime],5-tetrachlorobiphenyl) has been detected in fish tissues from various sites in North America. The embryotoxicity of this compound to medaka (Oryzias latipes) and the induction of hepatic aryl hydrocarbon hydroxylase (AHH) in rainbow trout (Oncorhynchus mykiss) were determined to assess the toxic potency of this compound relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and two other non-ortho-substituted PCB compounds, congener 77 (3,3[prime],4,4[prime]-tetrachlorobiphenyl) and congener 126 (3,3[prime],4,4[prime],5-pentachlorobiphenyl). The TCDD toxic equivalency factors (TEFs) estimated for congener 81 from two end points in the medaka embryotoxicity assay were 0.0014 (from mortality data) and 0.006 (from swim bladder inflation data). The TEF estimated for congener 81 from data on AHH induction in rainbow trout was 0.004. All TEFs were greater than those estimated for congener 77 but were less than the TEFs estimated for congener 126. On the basis of these toxicity data, it is suggested that this congener may contribute significantly to the toxic burden of planar halogenated aromatic hydrocarbon in fish.
- OSTI ID:
- 7171316
- Journal Information:
- Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 13:9; ISSN ETOCDK; ISSN 0730-7268
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
CHLORINATED AROMATIC HYDROCARBONS
DIOXIN
FISHES
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
POLLUTION
POLYCHLORINATED BIPHENYLS
SENSITIVITY
TOXICITY
VERTEBRATES
WATER POLLUTION