Potency of 3,3{prime},4,4{prime},5-pentachlorobiphenyl (PCB 126) and 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), to produce lake trout early life stage mortality
- Univ. of Wisconsin, Madison, WI (United States)
- Environmental Protection Agency, Duluth, MN (United States)
Toxic equivalency factors (TEFs) relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been determined in rainbow trout for certain polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) using endpoints of early life stage mortality. Rainbow trout are a convenient model fish species. However, one of the major species at risk in the Great Lakes, and the fish species most sensitive to TCDD, is lake trout. The current study sought to (1) determine in lake trout the toxic potency of 3,3{prime},4,4{prime},5-pentachlorobiphenyl (PCB 126) in order to test the validity of generalizing TEFs across related species and (2) determine whether PCB 126 and TCDD act in an additive manner at a ratio similar to that found in feral lake trout eggs from the Great Lakes. Newly fertilized lake trout (Salvelinus namaycush) eggs were exposed to TCDD, PCB 126, or their combination at a ratio of 75:1, and sac fry mortality was used to determine toxic potencies. Signs of PCB 126 toxicity in lake trout early life stages were yolk-sac edema, multifocal hemorrhages, craniofacial malformations and mortality, identical to toxicity caused by TCDD. The TEF for PCB 126 was 0.003, which is similar to the TEF of 0.005 determined for rainbow trout early life stage mortality, suggesting that TEFs for the same endpoint are similar across related fish species. The dose-response curve for the congener mixture based on TCDD toxic equivalence was not significantly different from TCDD alone, suggesting that the congener combination acted additively to produce lake trout early life stage mortality.
- OSTI ID:
- 203626
- Report Number(s):
- CONF-9511137-; ISBN 1-880611-03-1; TRN: IM9614%%138
- Resource Relation:
- Conference: 2. Society of Environmental Toxicology and Chemistry (SETAC) world conference, Vancouver (Canada), 5-9 Nov 1995; Other Information: PBD: 1995; Related Information: Is Part Of Second SETAC world congress (16. annual meeting): Abstract book. Global environmental protection: Science, politics, and common sense; PB: 378 p.
- Country of Publication:
- United States
- Language:
- English
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