Surface-enhanced Raman analysis of Benzo(A)Pyrene-DNA adducts on silver-coated cellulose substrates
Journal Article
·
· Appl. Spectrosc.; (United States)
Benzo(a)pyrene-7,8 -diol-9,10 epoxide (BPDE-)-DNA adducts have been analyzed by surface-enhanced Raman scattering (SERS) spectrometry. BPDE is the ultimate carcinogenic metabolite of benzo(a)pyrene. The SERS measurements were performed with the use of a silver-coated cellulose material as the SERS-active substrate. The acid hydrolyzed products of BPDE-DNA adducts, DNA, and the BP-tetrols were also analyzed by SERS. The results indicate that SERS has great promise as a tool for detecting BPDE-DNA adducts in biological samples.
- Research Organization:
- Advanced Monitoring Developement Group, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6358796
- Journal Information:
- Appl. Spectrosc.; (United States), Journal Name: Appl. Spectrosc.; (United States) Vol. 41:4; ISSN APSPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
ADDUCTS
AROMATICS
BENZOPYRENE
CARCINOGENS
CHEMICAL ANALYSIS
CONDENSED AROMATICS
DNA ADDUCTS
HYDROCARBONS
LASER SPECTROSCOPY
METABOLITES
ORGANIC COMPOUNDS
RAMAN SPECTROSCOPY
SENSITIVITY
SPECTROSCOPY
400102* -- Chemical & Spectral Procedures
ADDUCTS
AROMATICS
BENZOPYRENE
CARCINOGENS
CHEMICAL ANALYSIS
CONDENSED AROMATICS
DNA ADDUCTS
HYDROCARBONS
LASER SPECTROSCOPY
METABOLITES
ORGANIC COMPOUNDS
RAMAN SPECTROSCOPY
SENSITIVITY
SPECTROSCOPY