Azidothymidine inhibits mitogen stimulated growth and DNA-repair in human peripheral lymphocytes

Journal Article · Fri Dec 30 04:00:00 EST 1988 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/S0006-291X(88)81026-X· OSTI ID:6351050

Munch-Petersen, B

Until now, 3'-Azido-3'-deoxythymidine (AZT) is the most widely used drug in AIDS therapy, but the positive anti HIV effect of the drug is often accompanied by severe side effects such as bone-marrow suppression. In the present study, the effect of AZT on UV induced DNA strand-break rejoining and on phytohemagglutinin stimulated growth of lymphocytes from 7 healthy volunteers has been examined, and inhibitory effects of the drug was observed at therapeutic concentrations, i.e. 1-10 uM AZT.

• Research Organization: Roskilde Univ. (Denmark)
• OSTI ID: 6351050
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 157:3; ISSN BBRCA
• Country of Publication: United States
• Language: English

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560120* -- Radiation Effects on Biochemicals
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL DIVISION
CONNECTIVE TISSUE CELLS
DNA REPAIR
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HETEROCYCLIC COMPOUNDS
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RIBOSIDES
SOMATIC CELLS
STRAND BREAKS
THYMIDINE
ULTRAVIOLET RADIATION
VERTEBRATES