Azidothymidine: crystal structure and possible functional role of the azido group

Journal Article · Tue Dec 01 04:00:00 EST 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.23.8239· OSTI ID:6215236

Camerman, A; Mastropaolo, D; Camerman, N

The crystal and molecular structures of the anti-acquired immunodeficiency syndrome agent 3'-azido-3'-deoxythymidine (AZT) have been determined by x-ray diffraction. There are two crystallographically independent AZT molecules in the crystal asymmetric unit; they have similar conformation and differ primarily in the glycosyl torsion angle. Comparisons with a hydrated thymidylate structure indicate that the azido group does not significantly affect the gross conformational preference of the molecule. The comparisons also suggest possible functional roles for the azido group in enzyme binding.

• Research Organization: Univ. of Washington, Seattle (USA)
• OSTI ID: 6215236
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:23; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
AZIDO COMPOUNDS
AZINES
COHERENT SCATTERING
CRYSTALLOGRAPHY
DIFFRACTION
DISEASES
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
MOLECULAR STRUCTURE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RIBOSIDES
SCATTERING
STEREOCHEMISTRY
THYMIDINE
VIRAL DISEASES
X-RAY DIFFRACTION