Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells
Journal Article
·
· Antimicrobial Agents and Chemotherapy; (USA)
- National Cancer Institute, Bethesda, MD (USA)
The effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (AZT) were studied in various human mononuclear cell preparations. Thymidine suppressed ({sup 3}H)AZT phosphorylation in the same concentration range (20 to 100 microM) in which it antagonizes the anti-human immunodeficiency virus activity of AZT. Uridine, in turn, had no influence on AZT phosphorylation, just as it has no effect on the anti-human immunodeficiency virus activity of AZT. These findings are consistent with a close relationship between the inhibition of AZT phosphorylation and the influence of physiological nucleosides on the antiviral activity of AZT.
- OSTI ID:
- 5803054
- Journal Information:
- Antimicrobial Agents and Chemotherapy; (USA), Journal Name: Antimicrobial Agents and Chemotherapy; (USA) Vol. 35:1; ISSN AMACC; ISSN 0066-4804
- Country of Publication:
- United States
- Language:
- English
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Journal Article
·
Thu Jan 31 23:00:00 EST 1991
· Molecular Pharmacology; (USA)
·
OSTI ID:6056480
Structure of the anti-human immunodeficiency virus agent 3 prime -fluoro-3 prime -deoxythymidine and electronic charge calculations for 3 prime -deoxythymidines
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Tue May 01 00:00:00 EDT 1990
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5201061
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· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6215236
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AIDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
KINETICS
LEUKOCYTES
MACROPHAGES
MAMMALS
MAN
MATERIALS
MONOCYTES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHAGOCYTES
PHOSPHORYLATION
PRIMATES
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
SOMATIC CELLS
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URACILS
URIDINE
VERTEBRATES
VIRAL DISEASES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AIDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
KINETICS
LEUKOCYTES
MACROPHAGES
MAMMALS
MAN
MATERIALS
MONOCYTES
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHAGOCYTES
PHOSPHORYLATION
PRIMATES
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
SOMATIC CELLS
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URACILS
URIDINE
VERTEBRATES
VIRAL DISEASES