Radioimmunoassay of serum myoglobin: evaluation and modification of a commercial kit and assessment of its usefulness for detecting acute myocardial infarction

Journal Article · Wed Nov 01 04:00:00 EST 1978 · Clin. Chem.; (United States)

OSTI ID:6340593

Kubasik, N P; Guiney, W; Warren, K; D'Souza, J P; Sine, H E; Brody, B B

We evaluated a modified procedure for a commercially available myoglobin radioimmunoassay kit (Nuclear Medical Systems). Within-run and run-to-run precision was acceptable. Normal ranges were established and parallelism studies performed. Clinical usefulness was assessed in 100 consecutive patients admitted to our coronary-care facility. The determinations were done daily, along with creatine kinase and its isoenzymes, and lactate dehydrogenase and its isoenzymes. Fifty of the 100 patients ultimately were shown to have had acute myocardial infarction. Myoglobinemia was present in most of the patients with acute myocardial infarction, but information on its presence was less useful clinically than was detection of creatine kinase isoenzyme MB.

• Research Organization: Genesee Hospital, Rochester, NY
• OSTI ID: 6340593
• Journal Information: Clin. Chem.; (United States), Journal Name: Clin. Chem.; (United States) Vol. 24:11; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD SERUM
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DIAGNOSIS
DISEASES
EVALUATION
GLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
MYOCARDIAL INFARCTION
MYOGLOBIN
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PIGMENTS
PORPHYRINS
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
TRACER TECHNIQUES