Measurement of total body calcium in osteoporotic patients treated with salmon calcitonin

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:6338014

Zanzi, I; Thompson, K; Cohn, S H

In the past, the evaluation of therapies for osteoporosis has been limited by the lack of a suitable quantitative end point. The introduction of the technique of in vivo total body neutron activation analysis (TBNAA) has made possible the precise and accurate measurement of total body calcium (TBCa). Since almost 99 percent of TBCa is in the skeleton, TBNAA gives a direct measurement of skeletal mass. Thus, changes in skeletal mass serve as an objective criterion in the evaluation of the efficacy of the therapy in osteoporosis. Studies performed at Brookhaven National Laboratory and elsewhere have reported the use of calcitonin (CT) in the treatment of primary osteoporosis and related conditions in a limited number of patients. The physiological effects of CT as an inhibitor of bone resorption has been the rationale of its use. The results of a randomized, controlled, 2 year therapeutical trial of CT in a group of postmenopausal osteoporotic women are presented in this report.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6338014
• Report Number(s): BNL-29673; CONF-8105102-1; ON: DE81024369
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ANALYSIS
ALKALINE EARTH METALS
ANIMALS
BARYONS
BODY
CALCITONIN
CALCIUM
CHEMICAL ANALYSIS
CHEMOTHERAPY
DATA
DISEASES
ELEMENTARY PARTICLES
ELEMENTS
EVALUATION
EXPERIMENTAL DATA
FEMALES
FERMIONS
HADRONS
HORMONES
IN VIVO
INFORMATION
MAMMALS
MAN
METALS
NEUTRONS
NUCLEONS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OSTEOPOROSIS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
SKELETAL DISEASES
SKELETON
THERAPY
VERTEBRATES
WOMEN