Measurement of total body calcium in osteoporotic patients treated with salmon calcitonin

Conference · Thu Jan 01 00:00:00 EST 1981

OSTI ID:6338014

Zanzi, I; Thompson, K; Cohn, S H

In the past, the evaluation of therapies for osteoporosis has been limited by the lack of a suitable quantitative end point. The introduction of the technique of in vivo total body neutron activation analysis (TBNAA) has made possible the precise and accurate measurement of total body calcium (TBCa). Since almost 99 percent of TBCa is in the skeleton, TBNAA gives a direct measurement of skeletal mass. Thus, changes in skeletal mass serve as an objective criterion in the evaluation of the efficacy of the therapy in osteoporosis. Studies performed at Brookhaven National Laboratory and elsewhere have reported the use of calcitonin (CT) in the treatment of primary osteoporosis and related conditions in a limited number of patients. The physiological effects of CT as an inhibitor of bone resorption has been the rationale of its use. The results of a randomized, controlled, 2 year therapeutical trial of CT in a group of postmenopausal osteoporotic women are presented in this report.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6338014
• Report Number(s): BNL-29673; CONF-8105102-1; ON: DE81024369; TRN: 81-013320
• Resource Relation: Conference: International symposium on osteoporosis, Jerusalem, Israel, 31 May 1981
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMOTHERAPY
EVALUATION
OSTEOPOROSIS
ACTIVATION ANALYSIS
CALCITONIN
CALCIUM
EXPERIMENTAL DATA
IN VIVO
NEUTRONS
SKELETON
WOMEN
ALKALINE EARTH METALS
ANIMALS
BARYONS
BODY
CHEMICAL ANALYSIS
DATA
DISEASES
ELEMENTARY PARTICLES
ELEMENTS
FEMALES
FERMIONS
HADRONS
HORMONES
INFORMATION
MAMMALS
MAN
METALS
NUCLEONS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
SKELETAL DISEASES
THERAPY
VERTEBRATES
550600* - Medicine
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