Metabolic products, mass spectral analyses, and synthesis of toxic trichothecenes. Final report, 15 April 1982-14 July 1985
Technical Report
·
OSTI ID:6336126
A mass spectral library of the trichothecenes was developed and delivered to USAMRIID. The structure of Fusarochromanone (causes bone deformation) was elucidated and the biological activity of this metabolite was determined. Metabolic studies of T-2 toxin were determined in chickens and the metabolites were identified. Similarly, a kinetic study of T-2 metabolism was done using a cow as the subject. De-epoxy-diacetoxyscirpenol was found in a Fusarium culture for the first time and de-epoxy-T2 tetraol was found in cow urine for the first time. Morphologic lesions of T-2 toxin in the cat were described.
- Research Organization:
- Minnesota Univ., St. Paul (USA)
- OSTI ID:
- 6336126
- Report Number(s):
- AD-A-180891/4/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
350000 -- Arms Control-- (1987-)
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION
ANTIGENS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL WARFARE AGENTS
DEFORMATION
FUNGI
FUSARIUM
MASS SPECTRA
MATERIALS
METABOLISM
METABOLITES
PARASITES
PLANTS
SPECTRA
TOXIC MATERIALS
TOXINS
URINE
WASTES
WEAPONS
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION
ANTIGENS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL WARFARE AGENTS
DEFORMATION
FUNGI
FUSARIUM
MASS SPECTRA
MATERIALS
METABOLISM
METABOLITES
PARASITES
PLANTS
SPECTRA
TOXIC MATERIALS
TOXINS
URINE
WASTES
WEAPONS