The oncogenic action of ionizing radiation on rat skin

Technical Report · Mon Jan 01 04:00:00 EST 1990

DOI:https://doi.org/10.2172/6320950· OSTI ID:6320950

Burns, F J; Garte, S J

An extensive experiment involving approximately 400 rats exposed to the neon ion beam at the Bevalac in Berkeley, CA and to electrons is nearing completion. Progress is described in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) oncogene activation in radiation-induced rat skin cancers; (3) DNA strand breaks in the epidermis as a function of radiation penetration. 59 refs., 4 tabs.

• Research Organization: New York Univ., NY (USA). Dept. of Environmental Medicine
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-87ER60539
• OSTI ID: 6320950
• Report Number(s): DOE/ER/60539-T3; ON: DE91002459
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CELL TRANSFORMATIONS
CHARGED PARTICLES
DISEASES
DNA
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ENERGY TRANSFER
EQUATIONS
GENES
IONIZING RADIATIONS
IONS
LET
MAMMALS
NEON IONS
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROGRESS REPORT
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SKIN
STRAND BREAKS
VERTEBRATES