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Title: (Oncogenic action of ionizing radiation)

Abstract

An extensive experiment involving approximately 400 rats exposed to the neon ion beam at the Bevalac in Berkeley, CA and to electrons is nearing completion. The carcinogenicity of energetic electrons was determined for comparison with the neon ion results. As in past reports we will describe progress in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) DNA strand breaks in the epidermis as a function of radiation penetration; (3) oncogene activation in radiation-induced rat skin cancers. 72 refs., 6 tabs.

Publication Date:
Research Org.:
New York Univ., NY (USA). Medical Center
Sponsoring Org.:
DOE/ER
OSTI Identifier:
6067179
Report Number(s):
DOE/ER/60539-T4
ON: DE91005979; TRN: 91-002358
DOE Contract Number:
FG02-87ER60539
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ELECTRONS; CARCINOGENESIS; NEON IONS; NEOPLASMS; RADIOINDUCTION; RATS; BIOLOGICAL RADIATION EFFECTS; SKIN; ONCOGENIC TRANSFORMATIONS; BIOLOGICAL PATHWAYS; DNA; DOSE-RESPONSE RELATIONSHIPS; EQUATIONS; IONIZING RADIATIONS; LET; ONCOGENES; PROGRESS REPORT; RADIATION PROTECTION; STRAND BREAKS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CELL TRANSFORMATIONS; CHARGED PARTICLES; DISEASES; DOCUMENT TYPES; ELEMENTARY PARTICLES; ENERGY TRANSFER; FERMIONS; GENES; IONS; LEPTONS; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 550400 - Genetics

Citation Formats

Not Available. (Oncogenic action of ionizing radiation). United States: N. p., 1990. Web. doi:10.2172/6067179.
Not Available. (Oncogenic action of ionizing radiation). United States. doi:10.2172/6067179.
Not Available. 1990. "(Oncogenic action of ionizing radiation)". United States. doi:10.2172/6067179. https://www.osti.gov/servlets/purl/6067179.
@article{osti_6067179,
title = {(Oncogenic action of ionizing radiation)},
author = {Not Available},
abstractNote = {An extensive experiment involving approximately 400 rats exposed to the neon ion beam at the Bevalac in Berkeley, CA and to electrons is nearing completion. The carcinogenicity of energetic electrons was determined for comparison with the neon ion results. As in past reports we will describe progress in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) DNA strand breaks in the epidermis as a function of radiation penetration; (3) oncogene activation in radiation-induced rat skin cancers. 72 refs., 6 tabs.},
doi = {10.2172/6067179},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1990,
month = 1
}

Technical Report:

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  • The carciongenic response of rat skin to ionizing radiation has been studied. A model of radiation carcinogenesis is being developed where it is assumed that the tumor yield can be related to moleuclar changes in the DNA occurring in phase 1 and that phase 2 exerts approximately the same effect on tumor development, regardless of the radiation dose. (ACR)
  • Progress is described in 3 general areas corresponding to the specific aims of the proposal, including DNA strand breaks in the epidermis as a function of radiation penetration; oncogene activation in radiation-induced rat skin cancers; and carcinogenesis in rat skin induced by the neon ion beam. Numerous experiments have established that DNA strand breaks per unit dose in the rat epidermis are reduced by about 60% when the radiation penetration is reduced from 1.0 mm to 0.2 mm. The activation of oncogenes in the radiation-induced rat skin cancers followed a pattern. Four highly malignant cancers exhibited activation of K-ras andmore » c-myc oncogenes, while the remaining 8 cancers exhibited only one or the other of these 2 oncogenes. Of 5 squamous carcinomas, 4 showed K-ras activation and 1 showed c-myc activation. Approximately 200 rats were exposed to the neon ion beam at the Bevalac in Berkeley, CA. The carcinogenicity of energetic electrons (2.0 MeV) was determined in conjunction with the neon ion experiment. It is too early to evaluate tumor incidence in the neon ion experiment, but for electrons an unusually large excess of connective tissue tumors, fibromas and sarcomas, have been observed so far. 59 refs., 2 tabs.« less
  • The track model is based on the general ideas inherent in quadratic theory of carcinogenesis, namely that two critical, dose-dependent events are necessary to start a cell on its progression to cancer. Other non-dose-dependent events may be involved in later stages. Later events probably occur in association with cell division so that the initial DNA damage is converted to a form that is transmissible. The model being developed here is based on the idea that the geometrical distribution of the initial lesions within the target cell is critical to the biological alteration that predisposes the cells to carcinogenesis. Experiments performedmore » which exposed rat skin to ionizing radiation are described with reference to the above model. 33 refs. (DT)« less
  • Progress is described in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) oncogene activation in radiation-induced rat skin cancers; (3) DNA strand breaks in the epidermis as a function of radiation penetration.
  • Progress is described in three areas corresponding to carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; oncogene activation in radiation-induced rat skin cancers; and DNA strand breaks in the epidermis as a function of radiation penetration. Approximately 200 rats were exposed to the neon ion beam at the Bevalac in Berkeley, CA. The carcinogenicity of energetic electrons (2.0 Mev) was determined for comparison with the neon ion results. For double skin thickness irradiations electrons there was an unusually large excess of connective tissue tumors, fibromas and sarcomas. Presumably the latter tumors aremore » occurring, because more connective tissue is exposed by deeply penetrating, i.e., energetic, beams. 13 refs.« less