(Oncogenic action of ionizing radiation)

Technical Report · Mon Jan 01 00:00:00 EST 1990

DOI:https://doi.org/10.2172/6067179· OSTI ID:6067179

An extensive experiment involving approximately 400 rats exposed to the neon ion beam at the Bevalac in Berkeley, CA and to electrons is nearing completion. The carcinogenicity of energetic electrons was determined for comparison with the neon ion results. As in past reports we will describe progress in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) DNA strand breaks in the epidermis as a function of radiation penetration; (3) oncogene activation in radiation-induced rat skin cancers. 72 refs., 6 tabs.

• Research Organization: New York Univ., NY (USA). Medical Center
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-87ER60539
• OSTI ID: 6067179
• Report Number(s): DOE/ER/60539-T4; ON: DE91005979; TRN: 91-002358
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ELECTRONS
CARCINOGENESIS
NEON IONS
NEOPLASMS
RADIOINDUCTION
RATS
BIOLOGICAL RADIATION EFFECTS
SKIN
ONCOGENIC TRANSFORMATIONS
BIOLOGICAL PATHWAYS
DNA
DOSE-RESPONSE RELATIONSHIPS
EQUATIONS
IONIZING RADIATIONS
LET
ONCOGENES
PROGRESS REPORT
RADIATION PROTECTION
STRAND BREAKS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL TRANSFORMATIONS
CHARGED PARTICLES
DISEASES
DOCUMENT TYPES
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
GENES
IONS
LEPTONS
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550400 - Genetics