(Oncogenic action of ionizing radiation)

Technical Report · Mon Jan 01 04:00:00 EST 1990

DOI:https://doi.org/10.2172/6067179· OSTI ID:6067179

An extensive experiment involving approximately 400 rats exposed to the neon ion beam at the Bevalac in Berkeley, CA and to electrons is nearing completion. The carcinogenicity of energetic electrons was determined for comparison with the neon ion results. As in past reports we will describe progress in three areas corresponding to the specific aims of the proposal: (1) carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; (2) DNA strand breaks in the epidermis as a function of radiation penetration; (3) oncogene activation in radiation-induced rat skin cancers. 72 refs., 6 tabs.

• Research Organization: New York Univ., NY (USA). Medical Center
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-87ER60539
• OSTI ID: 6067179
• Report Number(s): DOE/ER/60539-T4; ON: DE91005979
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CELL TRANSFORMATIONS
CHARGED PARTICLES
DISEASES
DNA
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ELECTRONS
ELEMENTARY PARTICLES
ENERGY TRANSFER
EQUATIONS
FERMIONS
GENES
IONIZING RADIATIONS
IONS
LEPTONS
LET
MAMMALS
NEON IONS
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROGRESS REPORT
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SKIN
STRAND BREAKS
VERTEBRATES