The oncogenic action of ionizing radiation on rat skin
Progress is described in three areas corresponding to carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; oncogene activation in radiation-induced rat skin cancers; and DNA strand breaks in the epidermis as a function of radiation penetration. Approximately 200 rats were exposed to the neon ion beam at the Bevalac in Berkeley, CA. The carcinogenicity of energetic electrons (2.0 Mev) was determined for comparison with the neon ion results. For double skin thickness irradiations electrons there was an unusually large excess of connective tissue tumors, fibromas and sarcomas. Presumably the latter tumors are occurring, because more connective tissue is exposed by deeply penetrating, i.e., energetic, beams. 13 refs.
- Research Organization:
- New York Univ., NY (USA). Dept. of Environmental Medicine
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- FG02-87ER60539
- OSTI ID:
- 5473028
- Report Number(s):
- DOE/ER/60539-T1; COO-3380-60; ON: DE90001535; TRN: 89-028989
- Country of Publication:
- United States
- Language:
- English
Similar Records
The oncogenic action of ionizing radiation on rat skin: Progress report, February 1, 1987-January 31, 1988
The oncogenic action of ionizing radiation on rat skin
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
NEOPLASMS
RADIOINDUCTION
ONCOGENES
GENE AMPLIFICATION
SKIN
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MODELS
CARCINOGENESIS
DNA
DOSE-RESPONSE RELATIONSHIPS
FORECASTING
IONIZING RADIATIONS
LET
PROGRESS REPORT
RADIATION PROTECTION
RATS
STRAND BREAKS
ANIMALS
BIOLOGICAL EFFECTS
BODY
DISEASES
DOCUMENT TYPES
ENERGY TRANSFER
FUNCTIONS
GENES
MAMMALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
550400 - Genetics