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The oncogenic action of ionizing radiation on rat skin

Technical Report ·
DOI:https://doi.org/10.2172/5473028· OSTI ID:5473028
Progress is described in three areas corresponding to carcinogenesis and DNA strand breaks in rat skin following exposure by the neon ions or electrons; oncogene activation in radiation-induced rat skin cancers; and DNA strand breaks in the epidermis as a function of radiation penetration. Approximately 200 rats were exposed to the neon ion beam at the Bevalac in Berkeley, CA. The carcinogenicity of energetic electrons (2.0 Mev) was determined for comparison with the neon ion results. For double skin thickness irradiations electrons there was an unusually large excess of connective tissue tumors, fibromas and sarcomas. Presumably the latter tumors are occurring, because more connective tissue is exposed by deeply penetrating, i.e., energetic, beams. 13 refs.
Research Organization:
New York Univ., NY (USA). Dept. of Environmental Medicine
Sponsoring Organization:
DOE/ER
DOE Contract Number:
FG02-87ER60539
OSTI ID:
5473028
Report Number(s):
DOE/ER/60539-T1; COO--3380-60; ON: DE90001535
Country of Publication:
United States
Language:
English