Effects of chronic treatment with cadmium on ATPases, uptake of catecholamines, and lipid peroxidation in rat brain synaptosomes

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Ecotoxicology and Environmental Safety; (USA)

DOI:https://doi.org/10.1016/0147-6513(90)90044-6· OSTI ID:6319193

Rajanna, B; Hobson, M; Boykin, M; Chetty, C S ^[1]

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1. Selma Univ., AL (USA)

The chronic effects of cadmium on specific activities of oligomycin-sensitive (OS) and -insensitive Mg{sup 2+} ATPase, Na(+)-K+ ATPase, lipid peroxidation, and uptake of catecholamines in brain synaptosomes of rats treated daily for 2 or 4 months were studied. Cadmium significantly decreased the specific activities of OS-Mg{sup 2+} ATPase, Na(+)-K+ ATPase, and uptake of ({sup 3}H)-dopamine ({sup 3}H-DA) and ({sup 3}H)norepinephrine ({sup 3}H-NE) and increased the lipid peroxidation.

• OSTI ID: 6319193
• Journal Information: Ecotoxicology and Environmental Safety; (USA), Journal Name: Ecotoxicology and Environmental Safety; (USA) Vol. 20:1; ISSN EESAD; ISSN 0147-6513
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ADRENAL HORMONES
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
ATP-ASE
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CADMIUM
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHRONIC EXPOSURE
DOPAMINE
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
HYDROGEN COMPOUNDS
HYDROLASES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LIPIDS
MAMMALS
METABOLISM
METALS
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PHOSPHOHYDROLASES
POLYPHENOLS
RATS
RODENTS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES