Effects of cadmium on the uptake of dopamine and norepinephrine in rat brain synaptosomes
Journal Article
·
· Bull. Environ. Contam. Toxicol.; (United States)
OSTI ID:5176506
Cadmium (Cd) a known environmental contaminant is neurotoxic. Kinetics of cadmium inhibition indicate that the metal may compete with ATP and Na/sup +/ sites on Na/sup +/-K/sup +/ ATPase in rat brain synaptosomes. Uptake and release processes of catecholamines into the central nervous system are dependent on membrane bound Na/sup +/-K/sup +/ ATPase. It is suggested that the uptake and release processes of dopamine (DA) and norepinephrine (NE) in neurons are energy utilizing and hence are dependent on active ion transport. If the two aforementioned mechanisms are truly interdependent, then any alteration caused by a toxin to either of the above two mechanisms should also cause a parallel change in the other. The purpose of this study was to examine in vitro effects of cadmium chloride on the uptake of DA and NE and the activity of ATPase in the rat brain synaptosome.
- Research Organization:
- Selma Univ., AL
- OSTI ID:
- 5176506
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 37:3; ISSN BECTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
ATP-ASE
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DOPAMINE
DRUGS
ENZYME ACTIVITY
ENZYMES
HALIDES
HALOGEN COMPOUNDS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PHOSPHOHYDROLASES
POLYPHENOLS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID ANHYDRASES
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
ATP-ASE
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DOPAMINE
DRUGS
ENZYME ACTIVITY
ENZYMES
HALIDES
HALOGEN COMPOUNDS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PHOSPHOHYDROLASES
POLYPHENOLS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES