Results of total body irradiation in the treatment of advanced non-Hodgkin's lymphomas
Total body irradiation (TBI) was used as primary therapy for 58 previously untreated patients with Stage III or IV non-Hodgkin's lymphoma (NHL). 150 rad was administered, with 15 rad fractions twice a week, with careful monitoring of hematologic status. Thrombocytopenia was the most frequent complication, which resolved in all except 4 patients. Survival at 8 years was 52%, with 14% relapse-free survival. Patients with nodular histology had a more favorable prognosis than those with diffuse histology (median relapse-free survival of 24 vs. 12 months). There were 2 cases of erythroeukemia, which occurred after combination chemotherapy was given for relapse. Though TBI can offer complete remission and extended survival in advanced NHL, most patients eventually relapse and it should not be considered as a curative mode of therapy.
- Research Organization:
- Peter Bent Brigham Hospital, Boston, MA
- OSTI ID:
- 6312030
- Journal Information:
- Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:3; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CHEMOTHERAPY
DATA
DATA FORMS
DISEASES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GRAPHS
INFORMATION
IRRADIATION
ISOLATED VALUES
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
PATIENTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY
WHOLE-BODY IRRADIATION