Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

New sensitive fluorometric method for measurement of vascular permeability

Journal Article · · J. Pharmacol. Methods; (United States)
A sensitive fluorometric method has been developed for the measurement of vascular permeability in carrageenin air-pouch inflammation in rats. Fluorescein isothiocyanate-labeled bovine serum albumin (F-BSA) was used as a tracer. This fluorometric method is as simple and reliable as the method using radioiodine-labeled human serum albumin and has the advantages of low cost, no health hazard, and the fact that F-BSA can be stored over a long period. This fluorometric method is probably applicable to other inflammation models such as pleurisy and peritonitis in which inflammatory exudate can be collected.
Research Organization:
Tohoku Univ., Sendai, Japan
OSTI ID:
6306032
Journal Information:
J. Pharmacol. Methods; (United States), Journal Name: J. Pharmacol. Methods; (United States) Vol. 11:3; ISSN JPMED
Country of Publication:
United States
Language:
English