Dimethylnitrosamine demethylase activity in Drosophila melanogaster

Journal Article · Tue Jun 15 04:00:00 EDT 1982 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(82)91778-8· OSTI ID:6299945

Waters, L C; Nix, C E; Epler, J L

A dimethylnitrosamine (DMN) demethylase with levels of activity comparable to that in uninduced rat liver was demonstrated in both larval and adult forms of the Hikone-R strain of Drosophila. A microsomal enzyme, it has many properties of a cytochrome P-450-containing mixed-function oxidase. Kinetic analysis indicates only a single enzyme with an apparent K/sub m/ of 10.5 mM DMN.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6299945
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 106:3; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALKYL RADICALS
AMINES
ANIMALS
ARTHROPODS
BIOCHEMICAL REACTION KINETICS
CELL CONSTITUENTS
DIPTERA
DROSOPHILA
ENZYME ACTIVITY
ENZYMES
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
KINETICS
METHYL RADICALS
MICROSOMES
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
RADICALS
REACTION KINETICS