Dimethylnitrosamine demethylase activity in Drosophila melanogaster

Journal Article · Tue Jun 15 04:00:00 EDT 1982 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(82)91778-8· OSTI ID:6143927

Waters, L C; Nix, C E; Epler, J L

A dimethylnitrosamine (DMN) demethylase with levels of activity comparable to that in uninduced rat liver was demonstrated in both larval and adult forms of the Hikone-R strain of Drosophila. A microsomal enzyme, it has many properties of a cytochrome P-450-containing mixed-function oxidase. Kinetic analysis indicates only a single enzyme with an apparent K/sub m/ of 10.5 mM DMN.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6143927
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 106:3; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
AMINES
ANIMALS
ARTHROPODS
BIOCHEMICAL REACTION KINETICS
CELL CONSTITUENTS
DATA
DIPTERA
DROSOPHILA
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
FLIES
FRUIT FLIES
INFORMATION
INSECTS
INVERTEBRATES
KINETICS
LIFE CYCLE
METABOLISM
MICROSOMES
MITOCHONDRIA
MIXED-FUNCTION OXIDASES
NITROSAMINES
NITROSO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
OXIDOREDUCTASES
OXYGENASES
REACTION KINETICS
SPECTRA