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Abnormal bone formation induced by implantation of osteosarcoma-derived bone-inducing substance in the X-linked hypophosphatemic mouse

Journal Article · · Bone; (United States)
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The X-linked hypophosphatemic mouse (Hyp) has been proposed as a model for the human familial hypophosphatemia (the most common form of vitamin D-resistant rickets). An osteosarcoma-derived bone-inducing substance was subcutaneously implanted into the Hyp mouse. The implant was consistently replaced by cartilage tissue at 2 weeks after implantation. The cartilage matrix seemed to be normal, according to the histological examination, and 35sulphur (TVS) uptake was also normal. Up to 4 weeks after implantation the cartilage matrix was completely replaced by unmineralized bone matrix and hematopoietic bone marrow. Osteoid tissue arising from the implantation of bone inducing substance in the Hyp mouse showed no radiologic or histologic sign of calcification. These findings suggest that the abnormalities of endochondral ossification in the Hyp mouse might be characterized by the failure of mineralization in cartilage and bone matrix. Analysis of the effects of bone-inducing substance on the Hyp mouse may help to give greater insight into the mechanism and treatment of human familial hypophosphatemia.

Research Organization:
Osaka Univ. Medical School, Japan
OSTI ID:
6294030
Journal Information:
Bone; (United States), Journal Name: Bone; (United States) Vol. 4; ISSN BONED
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE TISSUES
CARTILAGE
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLIC DISEASES
MICE
MINERALIZATION
NEOPLASMS
NUCLEI
OSTEOSARCOMAS
PATHOGENESIS
RADIOISOTOPES
RICKETS
RODENTS
SARCOMAS
SKELETAL DISEASES
SULFUR 35
SULFUR ISOTOPES
TISSUES
UPTAKE
VERTEBRATES