INTERMITTENT BONE CHANGES AND MULTIPLE CARTILAGE DEFECTS IN CHRONIC STRONTIUM RICKETS IN RATS
Young (3-week-old) and adult rats were fed a stock diet containing 1.5% Ca, 1.8% Sr, and 0.90% P. Continuous Sr feeding first induced typical rickets in young rats receiving adequate Ca, P, and vitamin D but later the widened cartilage spontaneously calcified intermittently leaving transverse bands consisting largely of osteoid tissue in the metaphysis; in addition to intermittent calcification, bone changes indicated that skeletal growth was not uniformly progressive. Subsequently areas of the epiphyseal cartilage failed to calcify and localized defects developed; among these are wedge-shaped metaphyseal osteoid tissue masses, invagination of the epiphyseal plate to form multiple nodules of cartilage with proliferating cells in the middle and hypertrophic ones at the periphery, perforation, and fragmentation of the epiphyseal plate with formation of large cartilage nodules. Multiple cartilage nodules of different sizes appeared in the epiphysis, metaphysis, and bone shaft. Most bone margins were lined by osteoid seams which only slowly calcified and concomitantly resoiption was decreased so that the rate of remodeling of the skeleton was diminished. This process may help to explain the results of treatment of osteoporosis by Sr administration. (BBB)
- Research Organization:
- Univ. of Melbourne
- NSA Number:
- NSA-18-000026
- OSTI ID:
- 4166027
- Journal Information:
- J. Bone Joint Surg., Journal Name: J. Bone Joint Surg. Vol. Vol: 44B
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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