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New bone formation and bone marrow differentiation induced in rats by extracellular bone matrix implantation: effect of local preirradiation on the process

Journal Article · · Exp. Hematol.; (United States)
OSTI ID:6471954
; ; ;

Subcutaneous implantation of demineralized diaphyseal rat bone matrix in ACI rats initiates a developmental cascade that results in the formation of new endochondral bone and an associated hematopoietic bone marrow differentiation. Irradiation (1500 rad, /sup 60/Co) of the implantation site 24 h prior to implantation suppresses the formation of endochondral bone and bone marrow. All phases of the developmental cascade, including chemotaxis, proliferation, and differentiation, are arrested by the irradiation. Simultaneous implantation with the extracellular matrix of bone marrow, bone, pieces of a four-day-old implant or of thoracic muscle--but not of brain, liver, or spleen tissue--results in the development of endochondral bone and bone marrow at the irradiated site. Concurrent implantation with the extracellular matrix of in vitro growing fibroblasts of marrow or ossicle origin does not restore the developmental cascade.

Research Organization:
Tel-Aviv Univ., Israel
OSTI ID:
6471954
Journal Information:
Exp. Hematol.; (United States), Journal Name: Exp. Hematol.; (United States) Vol. 4; ISSN EXHMA
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ALKALINE PHOSPHATASE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE CELLS
BONE MARROW
CALCIUM
CARTILAGE
CELL DIFFERENTIATION
CELL PROLIFERATION
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
ELEMENTS
ENZYMES
ESTERASES
FIBROBLASTS
HEMATOPOIETIC SYSTEM
HYDROLASES
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOCAL IRRADIATION
MAMMALS
METALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PHOSPHATASES
RADIATION EFFECTS
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES