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Possibilities and problems in uv radiation carcinogenesis experiments

Conference ·
OSTI ID:6293941
Experiments were designed to solve problems in dose-response relationships in uv-induced carcinogenesis. Two strains of hairless mice were exposed to 300 to 400 nm, 320 to 400 nm, and 365 nm wavelength emissions following exposure to 8-methoxy-psoralen; various fractionation regimes were used. Results showed that the number of psoralen-DNA crosslinks per cell increased linearly with dose. The importance of wavelength in the initiation and the expression of tumors is emphasized. (HLW)
Research Organization:
Oak Ridge National Lab., TN (USA); Argonne National Lab., IL (USA)
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6293941
Report Number(s):
CONF-7809133-1
Country of Publication:
United States
Language:
English