Photosensitized reactions and carcinogenesis

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Natl. Cancer Inst. Monogr.; (United States)

OSTI ID:5300390

Fry, R J.M.; Ley, R D; Grube, D D

Data is presented from experiments designed to investigate the role of DNA interstrand cross-links induced by exposure to 8-MOP plus UVR and skin carcinogensis. 8-MOP was administered topically to two strains of hairless mice, SKH:hair-less-1 and HRS/J/An1, which were then exposed to uv light sources with emission in the range of (1) 300 to 400, (2) 320 to 400, and (3) predominantly 365 nm. We found no strain dependency for DNA cross-link production, but a marked strain-dependent difference occurred in tumor incidence when TPA was administered after exposure to 8-MOP nd 320 to 400 nm. These results suggest that the events concerned with tumor promotion are dependent on strain. Because the most effective tumorigenic wavelength specrum was 300 to 400 nm, we investigated the possibility of interaction between lesions induced by the 300- to 320-nm wavelengths and the psoralen photoadducts. In the course of this experiment, we found that the tumorigenic effect was also dependent on the time interval between exposures to 8-MOP plus 365-nm light.

• OSTI ID: 5300390
• Journal Information: Natl. Cancer Inst. Monogr.; (United States), Journal Name: Natl. Cancer Inst. Monogr.; (United States) Vol. 50; ISSN NCIMA
• Country of Publication: United States
• Language: English

Related Subjects

560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CARCINOGENS
CHEMICAL REACTIONS
COUMARIN
CROSS-LINKING
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
LACTONES
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATHOGENESIS
PHOTOCHEMICAL REACTIONS
PHOTOSYNTHESIS
POLYMERIZATION
PSORALEN
PYRANS
RADIATIONS
RODENTS
SKIN
SYNTHESIS
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES