Gated and cinematic perfusion lung imaging in dogs with experimental pulmonary embolism. [/sup 99m/Tc-macroaggregated albumin and -microsphere scanning]
To determine how pulmonary respiratory motion affects detection of pulmonary emboli, 11 dogs had routine lung scans and gated or cinematic perfusion images after undergoing autologous experimental pulmonary embolism. Six dogs had routine six-view perfusion studies, plus end-inspiratory and end-expiratory gated perfusion studies performed with a physiologic synchronizer set to 80% threshold. Five other dogs had three-view ungated and cinematic (post., LPO, RPO) perfusion images. Cinematic studies were acquired by synchronizing a camera-computer system to the Harvard respirator that ventilated the dog. Before death, all animals received i.v. India ink to outline pulmonary perfusion defects, and postmortem lung dissection verified sites of emboli. An ROC curve analysis of randomized perfusion studies showed that end-inspiratory gated images yielded true-positive rates 5 to 10% higher than ungated images at any given false-positive rate. Lesion detection by cinematic studies was comparable to detection by ungated images, but detection by end-expiratory images was worse. End-inspiratory gated imaging may be useful as an occasional adjunct to routine perfusion lung imaging.
- Research Organization:
- Johns Hopkins Medical Institutions, Baltimore, MD
- OSTI ID:
- 6289984
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:5
- Country of Publication:
- United States
- Language:
- English
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DIAGNOSTIC TECHNIQUES
COMPARATIVE EVALUATIONS
EMBOLI
DIAGNOSIS
LUNGS
SCINTISCANNING
RESPIRATORY SYSTEM DISEASES
TECHNETIUM 99
ALBUMINS
DOGS
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
LABELLED COMPOUNDS
MICROSPHERES
PERFUSED ORGANS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics