Ventilation-perfusion lung imaging and selective pulmonary angiography in dogs with experimental pulmonary embolism. [/sup 99m/Tc and /sup 133/Xe tracer techniques]

Journal Article · Wed Feb 01 04:00:00 EST 1978 · J. Nucl. Med.; (United States)

OSTI ID:7277120

Alderson, P O; Doppman, J L; Diamond, S S; Mendenhall, K G; Barron, E L; Girton, M

To determine the accuracy and limitations of Xe-133 ventilation and Tc-99m perfusion lung images (V-P images) in detecting pulmonary emboli (PE), these studies were performed in 23 dogs after experimental production of PE by a modified Wessler technique. Fourteen of the animals also underwent selective pulmonary angiography. Xenon-133 abnormalities were seen immediately after embolization in two of the 23 animals (8.7 percent). Perfusion images revealed the location of 83 percent of emboli that completely obstructed pulmonary vessels, but only 26 percent of those that partially obstructed flow. Defects were seen with 97 percent of emboli that completely occluded vessels larger than 2.0 mm in diameter, but in only 66 percent of those occluding smaller vessels. Oblique perfusion images provided the only evidence of the perfusion defect associated with five of 88 (5.7 percent) angiographically proven emboli. V-P imaging is a sensitive technique for detecting PE unless the emboli lodge in very small vessels or incompletely obstruct a vessel. Xenon-133 abnormalities occur infrequently following PE, and should not be a common cause for a false-negative V-P match in clinical practice.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 7277120
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DOGS
EMBOLI
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERFUSED ORGANS
PHYSIOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RESPIRATORY SYSTEM
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES