Influence of left ventricular volume and wall motion on myocardial images. [/sup 201/Tl, /sup 99m/Tc-albumin microspheres]

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.59.6.1172· OSTI ID:5932455

Gewirtz, H; Groette, G J; Strauss, H W; O'Keefe, D D; Akins, C W; Daggett, W M; Pohost, G M

We studied 10 dogs to determine if changes in myocardial images could result from alterations in left ventricular (LV) geometry independent of any change in tracer distribution. All dogs received 20 mCi of /sup 99m/Tc-labeled albumin microspheres (10-45..mu..) via the left atrium, after which control multigated, gated, and ungated myocardial perfusion images were obtained. Next, five dogs were sequentially imaged (1) during partial aortic occlusion to increase LV volume; (2) after release of the aortic occlusion; (3) after ligation of the coronary vasculature of the apex of the LV to produce regional dyskinesis; and (4) after nitroprusside induced hypotension to decrease ventricular volume. Only ligation and nitroprusside studies were done in the remaining five dogs. We gave 1.5 mCi of thallium-201 intravenously to two other dogs and obtained sequential ungated control, ligation, and nitroprusside images. At postmortem exam, tracer activity was equivalent at the apex and base for both microspheres and thallium. Nevertheless, partial aortic occlusion caused defects in the apex and anterior wall in four of five dogs. Coronary ligation caused new defects in eight of 10 dogs given microspheres and in both dogs given thallium. With nitroprusside, microsphere and thallium defects generally decreased in size. Gated images showed that defects caused by ligation tended to be larger in end-systole than in end-diastole, while all partial aortic occlusion-induced defects were equal or greater in size in end-diastole compared with end-systole. These results indicate that changes in LV geometry or contraction pattern may cause defeccts on myocardial images without any change in tracer distribution.

• Research Organization: Massachusetts General Hosptial, Boston
• OSTI ID: 5932455
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 59:6; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
GEOMETRY
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATHEMATICS
MICROSPHERES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
VERTEBRATES
VOLUME
YEARS LIVING RADIOISOTOPES