Cellular effects of UVA: DNA damages
Ultraviolet radiation between 320 nm and visible light (UVA) is a major component of both solar radiation and suntan lamps, which are being increasingly used in tanning booths. UVA has generally been considered innocuous, partially because DNA does not absorb appreciably in this region, but UVB radiation (290-320 nm) has widely been considered to be the major etiological factor in human skin carcinogenesis caused by solar uv radiation, largely because DNA absorbs photons of UVB, which is known to produce thymine photoproducts (cyclobutane dimers and adducts). It is true that patients with xeroderma pigmentosum are particularly prone to solar-uv-induced skin cancer, and cells derived from these people have been shown to lack ability to repair pyrimidine photoproducts by excision, evidence that pyrimidine photoproducts might play a role in carcinogenesis in certain specialized situations. Normal cells have the ability to repair these UVB-induced lesions. However, UVA is considerably more penetrating and more abundant than UVB, and others have performed a spectral analysis that claimed that 20-60% (depending upon the solar zenith angle) of the toxic biological effects of solar radiation can be attributed to UVA. The fact that UVA radiations are mutagenic provides motivation for studying DNA changes that might be effected by this region of the electromagnetic spectrum.
- Research Organization:
- Argonne National Lab., IL (USA)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6289610
- Report Number(s):
- CONF-8810345-1; ON: DE89009866
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGY
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DNA
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
MODIFICATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHYSICAL RADIATION EFFECTS
RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOBIOLOGY
SOLAR RADIATION
STELLAR RADIATION
TOXICITY
ULTRAVIOLET RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGY
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DNA
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
MODIFICATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHYSICAL RADIATION EFFECTS
RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOBIOLOGY
SOLAR RADIATION
STELLAR RADIATION
TOXICITY
ULTRAVIOLET RADIATION