Prevention and treatment of the gastric symptoms of radiation sickness

Technical Report · Thu Dec 31 23:00:00 EST 1987

OSTI ID:6289311

Dubois, A; Fiala, N

The new antiemetic and gastrokinetic agent zacopride was tested in rhesus monkeys to assess its behavioral toxicity and its ability to inhibit radiation-induced emesis. Zacopride (intragastric, 0.3 mg/kg) or a placebo was given blindly and randomly in the basal state and 15 min before a whole-body 800 cG Co-60 gamma radiation dose (except for the legs which were partially protected to permit survival of some bone marrow). The authors determined 1) gastric emptying rates; 2) the presence and frequency of retching and vomiting; and 3) the effect of zacopride on the performance of a visual discrimination task in nonirradiated subjects. When given after the first vomiting episode in a separate group of irradiated monkeys, zacopride completely prevented any subsequent vomiting. Results demonstrate that intragastric administration of zacopride significantly inhibited radiation-induced retching, vomiting, and suppression of gastric emptying in rhesus monkeys and did not cause detectable behavioral side effects when given to nonradiated monkeys.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 6289311
• Report Number(s): AD-A-201972/7/XAB; AFRRI-SR-88-20
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BONE MARROW
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LEGS
LIMBS
MAMMALS
MONKEYS
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
STOMACH
TISSUES
TOXICITY
VERTEBRATES
VISION
WHOLE-BODY IRRADIATION