Radioprotectants and gastric function. Final report, 1 August 1985-31 December 1988
Technical Report
·
OSTI ID:6262690
The objectives of this project, therefore are to evaluate (1) the emetic properties of radioprotectants of the WR2721 family in monkeys in relation to modifications of gastrointestinal motility; (2) the role of the area postrema in WR2721-induced vomiting and gastric suppression; and (3) the possibility of preventing the side effects of radioprotectants with antiemetics. During this period the investigators have continued to study the emetic effects of WR2721 in monkeys, and have measured the concurrent action of this radioprotectant on gastic motility and gastric emptying of liquids and solids. In addition, they have determined the role of the area postrema in WR2721-induced vomiting and gastric suppression in beagle dogs. Finally, they evaluated the possibility of preventing WR2721-induced vomiting with zacopride.
- Research Organization:
- Uniformed Services Univ. of the Health Sciences, Bethesda, MD (USA)
- OSTI ID:
- 6262690
- Report Number(s):
- AD-A-227447/0/XAB
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
DIGESTIVE SYSTEM
DOCUMENT TYPES
DOGS
DRUGS
ELECTROPHYSIOLOGY
EVALUATION
GASTROINTESTINAL TRACT
MAMMALS
MONKEYS
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PROGRESS REPORT
RADIATION PROTECTION
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