Preparation of tritium-labeled optical isomers of amino acids by ligand exchange chromatography on polyacrylamide sorbent containing L-phenylalanine groupings

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Sov. Radiochem. (Engl. Transl.); (United States)

OSTI ID:6288398

Zolotarev, Yu A; Penkina, V I; Dostavalov, I N; Myasoedov, N F

Tritium-labeled optically active amino acids are obtained by resolving racemates of the corresponding amino acids by chromatography on a chiral polyacrylamide sorbent, filled with copper ions. The chiral sorbent is obtained by the action of formaldehyde and L-phenylalanine on a Biogel P-4 polyacrylamide gel in an alkaline medium. Data are given on the ligand exchange chromatography of amino acids on this sorbent, depending on the degree of filling of the sorbent by copper ions and the concentration of the eluent. Conditions were selected for the quantitative resolution of racemates of amino acids and examples are given of a preparative obtaining of tritium labeled optical isomers of amino acids.

• OSTI ID: 6288398
• Journal Information: Sov. Radiochem. (Engl. Transl.); (United States), Journal Name: Sov. Radiochem. (Engl. Transl.); (United States) Vol. 30:2; ISSN SVRDA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
ADSORBENTS
ALDEHYDES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHROMATOGRAPHY
COLLOIDS
COPPER COMPOUNDS
DISPERSIONS
FORMALDEHYDE
GELS
HYDROGEN ISOTOPES
ION EXCHANGE CHROMATOGRAPHY
ISOMERS
ISOTOPES
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
LABELLING
LIGANDS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
OPTICAL ACTIVITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
PHENYLALANINE
POLYAMIDES
POLYMERS
RADIOISOTOPES
SEPARATION PROCESSES
SYNTHESIS
TRANSITION ELEMENT COMPOUNDS
TRITIUM
TRITIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES