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Stability of cefazolin sodium admixtures in plastic bags after thawing by microwave radiation

Journal Article · · Am. J. Hosp. Pharm.; (United States)
OSTI ID:6279119
; ; ; ; ;
The effect on antibiotic stability of thawing, with microwave radiation, cefazolin sodium admixtures frozen in polyvinyl chloride minibags was studied. Two brands of cefazolin sodium (Ancef and Kefzol) were reconstituted and placed in 50- and 100-, and 250-ml polyvinyl chloride minibags of 5% dextrose in water or 0.9% sodium chloride. The resulting solutions were assayed for antibiotic stability, using an agar disk diffusion technique, and for pH. The solutions were then stored at -20/sup 0/C for 48 hours, thawed to room temperature in a microwave oven, and kept at room temperature for four hours, after which they were reassayed for potency and pH. The results indicated that after the freeze-thaw process, the cefazolin sodium minibag admixtures retained at least 90% of their initial antimicrobial activity. The minimal pH changes could not be related to changes in antimicrobial activity, and no color changes could be detected visually. Using a microwave oven can greatly reduce thawing time of antibiotic admixtures. To maintain solution stability and prevent accidents, it is important to calibrate the oven, avoid solution overheating, and observe full precautions in oven operation.
Research Organization:
Ohio State Univ. Hospitals, Columbus
OSTI ID:
6279119
Journal Information:
Am. J. Hosp. Pharm.; (United States), Journal Name: Am. J. Hosp. Pharm.; (United States) Vol. 37:2; ISSN AJHPA
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
550700 -- Microbiology
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY
FREEZING
HEAT
MATERIALS
MICROWAVE RADIATION
PETROCHEMICALS
PETROLEUM PRODUCTS
PH VALUE
PLASTICS
RADIATIONS
STABILITY
STORAGE
SYNTHETIC MATERIALS
THAWING