Effect of microwave radiation on the stability of frozen cefoxitin sodium solution in plastic bags

Journal Article · Sun Nov 01 04:00:00 EST 1981 · Am. J. Hosp. Pharm.; (United States)

OSTI ID:5386464

Stiles, M L

The effect of microwave radiation on the stability of frozen cefoxitin sodium solutions was investigated. The i.v. fluids used as vehicles for the 1-g admixtures of cefoxitin sodium were 5% dextrose injection and 0.9% sodium chloride injection in 50-ml and 100-ml polyvinyl chloride flexible containers. The antibiotic small-volume parenteral solutions were frozen at -20 degrees C for 72 hours and thawed by microwave radiation. Before and after the freeze-thaw process, the solutions were observed for changes in appearance with a light and dark field visual surveillance technique. In addition, pH determinations were made with a microprocessor ionanalyzer, and high-performance liquid chromatographic determinations of concentration were performed. No significant drug concentration changes were detected and no visible changes were observed. The pH changes were minimal. Microwave radiation can reduce thawing time of antibiotic admixtures. In this study, the stability of cefoxitin sodium solutions was not affected by the freeze-thaw process.

• Research Organization: College of Pharmacy, University of Oklahoma, Oklahoma City
• OSTI ID: 5386464
• Journal Information: Am. J. Hosp. Pharm.; (United States), Journal Name: Am. J. Hosp. Pharm.; (United States) Vol. 38:11; ISSN AJHPA
• Country of Publication: United States
• Language: English

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54 ENVIRONMENTAL SCIENCES
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DRUGS
ELECTROMAGNETIC RADIATION
MICROWAVE RADIATION
PH VALUE
PHARMACOLOGY
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
STORAGE LIFE
THAWING