Inhalation developmental toxicology studies: Teratology study of methyl ethyl ketone in mice: Final report
Methyl ethyl ketone (MEK) is a widely used industrial solvent which results in considerable human exposure. In order to assess the potential for MEK to cause developmental toxicity in rodents, four groups of Swiss (CD-1) mice were exposed to 0, 400, 1000 or 3000 ppM MEK vapors, 7 h/day, 7 dy/wk. Ten virgin females and approx.30 plug-positive females per group were exposed concurrently for 10 consecutive days (6--15 dg for mated mice). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 18 dg. Uterine implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Exposure of pregnant mice to these concentrations of MEK did not result in apparent maternal toxicity, although there was a slight, treatment-correlated increase in liver to body weight ratios which was significant for the 3000-ppM group. Mild developmental toxicity was evident at 3000-ppM as a reduction in mean fetal body weight. This reduction was statistically significant for the males only, although the relative decrease in mean fetal body weight was the same for both sexes. 17 refs., 4 figs., 10 tabs.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6277861
- Report Number(s):
- PNL-6833; ON: DE89009563; TRN: 89-010200
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KETONES
TOXICITY
MICE
MORTALITY
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
INHALATION
LIFE SPAN
LITTER SIZE
MALFORMATIONS
PRENATAL EXPOSURE
PROGRESS REPORT
SEX DEPENDENCE
TERATOGENESIS
TIME DEPENDENCE
ANIMALS
DOCUMENT TYPES
INTAKE
MAMMALS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology