Inhalation developmental toxicology studies: Teratology study of n-hexane in rats: Final report

Technical Report · Tue Dec 01 04:00:00 EST 1987

DOI:https://doi.org/10.2172/5440289· OSTI ID:5440289

Mast, T J

The straight chain hydrocarbon, n-hexane, is a volatile, ubiquitous solvent used in industrial, academic, and smaller commercial environments. The significant opportunity for women of child-bearing age to be exposed to this chemical prompted the undertaking of a study to assess the developmental toxicity of n-hexane in an animal model. Timed-pregnant (30 animals per group) and virgin (10 animals per group) Sprague-Dawley rats were exposed to 0 (filtered air), 200, 1000, and 5000 ppM n-hexane (99.9% purity) vapor in inhalation chambers for 20 h/day for a period of 14 consecutive days. Sperm-positive females were exposed for 6 to 19 days of gestation (dg) and virgins were exposed concurrently for 14 consecutive days. The day of sperm detection was designated as 0 dg for mated females. Adult female body weights were monitored prior to, throughout the exposure period, and at sacrifice. Uterine, placental, and fetal body weights were obtained for gravid females at sacrifice. Implants were enumerated and their status recorded as live fetus, early or late resorption, or dead. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 16 refs., 3 figs., 7 tabs.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5440289
• Report Number(s): PNL-6453; ON: DE88006812
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANIMALS
CONGENITAL MALFORMATIONS
DOCUMENT TYPES
FETUSES
HEXANE
HYDROCARBONS
INHALATION
INTAKE
MALFORMATIONS
MAMMALS
MATTER
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRENATAL EXPOSURE
PROGRESS REPORT
RATS
RODENTS
SEX DEPENDENCE
TERATOGENESIS
TIME DEPENDENCE
TOXICITY
VERTEBRATES
VOLATILE MATTER