Biphasic control of polymorphonuclear cell migration by Kupffer cells. Effect of exposure to metabolic products of ethanol

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90064-1· OSTI ID:6277531

Fainsilber, Z; Feinman, L; Shaw, S; Lieber, C S

In order to investigate the role of the Kupffer cells in the regulation of the inflammatory reaction seen in alcoholic hepatitis, rat liver Kupffer cells were cultured and exposed to products of ethanol metabolism. The resultant supernatants were tested to study their ability to stimulate or inhibit polymorphonuclear cell chemotaxis. Kupffer cells produced increased chemokinetic activity for human polymorphonuclear leukocytes; when incubated with soluble products of microsomal peroxidation, the Kupffer cells engendered more chemokinetic activity than that produced by untreated Kupffer cells. When Kupffer cells were incubated with acetaldehyde, the chemokinetic activity that appeared in the supernatant did not differ from control. Chemotaxis of polymorphonuclear cells was not observed when the Kupffer cell supernatants were tested by checkerboard analysis.

• Research Organization: Veterans Administration Medical Center, Bronx, NY (USA)
• OSTI ID: 6277531
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 43:7; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETALDEHYDE
ALCOHOLS
ALDEHYDES
ANIMAL CELLS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
DIGESTIVE SYSTEM DISEASES
DISEASES
ETHANOL
FUNCTIONS
HEPATITIS
HYDROXY COMPOUNDS
LEUKOCYTES
MATERIALS
METABOLISM
METABOLITES
MICROSOMES
NEUTROPHILS
ORGANIC COMPOUNDS
ORGANOIDS
PHAGOCYTES
SOMATIC CELLS