Influence of ethanol on human T-lymphocyte migration
Journal Article
·
· J. Lab. Clin. Med.; (United States)
OSTI ID:5863079
Because ethanol consumption is associated with increased susceptibility to infection, an examination was made of the effects of ethanol and its metabolite acetaldehyde on human T-lymphocyte migration, an important functional component of cellular inflammatory responses. With a modified Boyden chamber system, ethanol at 0.25% and 0.50% (vol/vol) inhibited spontaneous motility of human T-lymphocytes, in a noncytotoxic manner, to 65% +/- 7% (mean +/- SEM) and 62% +/- 7% of control values of migration, respectively. When T-lymphocyte migration was stimulated by colchicine (10/sup -5/ mol/L), incubation with ethanol (0.25% and 0.50%, vol/vol) decreased migration to 80% +/- 4% and 66% +/- 8% of control values, respectively. Similar degrees of inhibition of migration were obtained with acetaldehyde at concentrations five to 10 times less than ethanol. Ethanol was similarly capable of inhibiting T cell migration induced by dibutyryl cyclic guanosine monophosphate, but it had no effect on stimulated migration induced by a human chemokinetic lymphokine. The study demonstrates that ethanol, at concentrations achievable in vivo, is capable of depressing T-lymphocyte migration. This effect might contribute to the immunosuppression associated with ethanol consumption. 36 references, 4 figures.
- Research Organization:
- Boston Univ. Medical Center, MA
- OSTI ID:
- 5863079
- Journal Information:
- J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 104:5; ISSN JLCMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETALDEHYDE
ALCOHOLS
ALDEHYDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA
ETHANOL
EXPERIMENTAL DATA
HYDROXY COMPOUNDS
IMMUNOSUPPRESSION
INFLAMMATION
INFORMATION
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
METABOLITES
NUMERICAL DATA
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
SOMATIC CELLS
SYMPTOMS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETALDEHYDE
ALCOHOLS
ALDEHYDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA
ETHANOL
EXPERIMENTAL DATA
HYDROXY COMPOUNDS
IMMUNOSUPPRESSION
INFLAMMATION
INFORMATION
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
METABOLITES
NUMERICAL DATA
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
SOMATIC CELLS
SYMPTOMS
VERTEBRATES