Effects of trichostatins on differentiation of murine erythroleukemia cells
The fungistatic antibiotics trichostatins (TS) A and C were isolated from culture broth of Streptomyces platensis No. 145 and were found to be potent inducers of differentiation in murine erythroleukemia (Friend and RV133) cells at concentrations of 1.5 X 10(-8) M for TSA and 5 X 10(-7) M for TSC. Differentiation induced by TS was cooperatively enhanced by UV irradiation but not by treatment with dimethyl sulfoxide. This enhanced activity was completely inhibited by adding cycloheximide to the culture medium 2 h after exposure to TS, suggesting that TS are dimethyl sulfoxide-type inducers of erythroid differentiation. No inhibitory effect of TS was observed on macromolecular synthesis in cultured cells.
- Research Organization:
- Univ. of Tokyo, Japan
- OSTI ID:
- 6274290
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 47:14; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Early events leading to erythroid differentiation in mouse Friend cells revealed by cell fusion experiments
Variation of radiation sensitivity of Friend Erythroleukemia cells cultured in the presence of the differentiation inducer DMSO
Related Subjects
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL DIFFERENTIATION
CYCLOHEXIMIDE
DISEASES
DMSO
DNA REPLICATION
DRUGS
ELECTROMAGNETIC RADIATION
FUNGICIDES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEMIC DISEASES
LEUKEMIA
MAMMALS
MICE
NEOPLASMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PESTICIDES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RNA
RODENTS
SULFOXIDES
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES