Radioimmunoscintigraphy of ovarian tumors using a new monoclonal antibody, SM-3

Journal Article · Sat Sep 01 04:00:00 EDT 1990 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(90)90093-Z· OSTI ID:6273915

Jobling, T W; Granowska, M; Britton, K E; Lowe, D G; Mather, S J; Burchell, J; Naeem, M; Shepherd, J H ^[1]

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1. St. Bartholomew's Hospital, London (England)

Radioimmunoscintigraphy with SM-3 monoclonal antibody produces results similar to those obtained with {sup 123}I-labeled HMFG-2. The tumor specificity of SM-3 in vitro is not as marked as that in vivo. SM-3 is, however, much easier to produce in tissue culture and, with the availability of {sup 99m}Tc labelling, has allowed radioimmunoscintigraphy to be done as an outpatient procedure. This technique has important implications for the continuing management of patients with ovarian cancer.

• OSTI ID: 6273915
• Journal Information: Gynecologic Oncology; (USA), Journal Name: Gynecologic Oncology; (USA) Journal Issue: 3 Vol. 38:3; ISSN GYNOA; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
GONADS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PATIENTS
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SENSITIVITY ANALYSIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES