Radioimmunodiagnosis of ovarian cancer using /sup 123/I-labelled, tumor-associated monoclonal antibodies

Journal Article · Sat Dec 31 23:00:00 EST 1983 · Cancer Detect. Prev.; (United States)

OSTI ID:6834173

Epenetos, A A; Shepherd, J; Britton, K E; Hawkins, L; Nimmon, C C; Taylor-Papadimitriou, J; Durbin, H; Malpas, J S; Mather, S; Granowska, M

Monoclonal antibodies to epithelial cells, antigenic determinants labelled with /sup 123/I and /sup 125/I, were administered to 10 immunodeficient mice bearing subcutaneous xenografts of human ovarian cancer. Radio scans of the body taken with a gamma camera at various time intervals demonstrated the presence of the cancer in all the mice. The smallest detectable tumor was approximately 1 mm in diameter. In a subsequent clinical study using /sup 123/I-labelled monoclonal antibodies in 10 patients with ovarian cancer, tumor detection was achieved in 8 patients, with tumor uptake of labelled antibody ranging between 0.2-2.6%. As a complementary method to existing forms of diagnosis, the targeting of monoclonal antibodies to ovarian cancer cells in vivo raises the hope of achieving early diagnosis in otherwise undetectable ovarian cancer, and provides encouragement to the concept of selective therapy in oncology.

• Research Organization: St. Bartholomew's Hospital, London, England
• OSTI ID: 6834173
• Journal Information: Cancer Detect. Prev.; (United States), Journal Name: Cancer Detect. Prev.; (United States) Vol. 7:1; ISSN CDPRD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE ISOTOPES
ISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
USES