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/sup 123/I radioiodinated antibody imaging of occult ovarian cancer

Journal Article · · Cancer (Philadelphia); (United States)
; ; ; ; ; ; ; ; ;

A monoclonal antibody HMFG2 labeled with iodine 123 was given to a patient who had ovarian cancer. The scan, taken 18 hours after administration of the antibody, demonstrated the presence and the position of residual tumor in the pelvis that was not previously detected by ultrasonography and computerized tomography (CT) scanning. The presence of the tumor was confirmed by surgery and histologic as well as immunoperoxidase examination of resected tissues. The tumor mass found was less than 0.8 cm in diameter. It is concluded that, in the search for residual or early ovarian cancer in the pelvis, monoclonal antibody scanning using /sup 123/I-labeled HMFG2 can complement ultrasonography and CT scanning.

Research Organization:
Imperial Cancer Research Fund, London, England
OSTI ID:
5828469
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 55:5; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CARBOXYLIC ACIDS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENZYMES
FEMALE GENITALS
GONADS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
OXIDOREDUCTASES
PATIENTS
PELVIS
PEROXIDASES
PORPHYRINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SURGERY
TOMOGRAPHY
TRACER TECHNIQUES
ULTRASONOGRAPHY