Strategies for the development of monoclonal antibodies for in vivo imaging: their use in the imaging of ovarian carcinoma

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Cancer Detect. Prev.; (United States)

OSTI ID:5598820

Burchell, J; Taylor-Papadimitriou, J; Griffiths, A B

There are a number of strategies that have been used for the development of monoclonal antibodies which recognize tumor associated antigens. These include the use of whole tumor cells or membrane components as the immunogen, and the use of differentiation antigens, for example the human milk fat globule. The monoclonal antibody HMFG-2 was developed using the latter strategy and has been shown to react with a large molecular weight mucin-like molecule which appears to be highly immunogenic in the mouse. The HMFG-2 antibody is proving to be extremely useful in the localization of ovarian tumors and is being used in a number of clinics. This antibody and its antigen have a number of characteristics which have contributed to its success in imaging ovarian carcinomas, including the repetitive nature of the antigenic epitope and the antibody's affinity.

• Research Organization: Imperial Cancer Research Fund, London, England
• OSTI ID: 5598820
• Journal Information: Cancer Detect. Prev.; (United States), Journal Name: Cancer Detect. Prev.; (United States); ISSN CDPRD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANTIBODIES
ANTIGENS
BODY
CARCINOMAS
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
FEMALE GENITALS
GONADS
HYBRIDOMAS
MONOCLONAL ANTIBODIES
NEOPLASMS
ORGANS
OVARIES
USES